Tuesday 22 September 2009

EBN has been widely used for enhancing immunocompetence

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Sent on: Sun Sep 13 11:28:35 2009
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1: Antiviral Res. 2006 Jul;70(3):140-6. Epub 2006 Mar 3. Compound (MeSH Keyword), Substance (MeSH Keyword), LinkOut
Edible bird's nest extract inhibits influenza virus infection.
Guo CT, Takahashi T, Bukawa W, Takahashi N, Yagi H, Kato K, Hidari KI, Miyamoto D, Suzuki T, Suzuki Y.
Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences and COE Program in the 21st century, Suruga-ku, Shizuoka 422-8526, Japan.

Edible bird's nest (EBN) is the nest of the swift that is made from its saliva. Although EBN has been widely used for enhancing immunocompetence, its antiviral efficacy has not been studied in detail. We found that EBN extract could strongly inhibit infection with influenza viruses in a host range-independent manner when it was hydrolyzed with Pancreatin F. Western blotting assay showed that the EBN extract bound to influenza virus. Furthermore, EBN extract could neutralize the infection of MDCK cells with influenza viruses and inhibit hemagglutination of influenza viruses to erythrocytes, but it could not inhibit the activity of influenza virus sialidase. Fluorometric HPLC indicated that the major molecular species of sialic acid in EBN is N-acetylneuraminic acid. The results suggest that EBN is a safe and valid natural source for the prevention of influenza viruses.

PMID: 16581142 [PubMed - indexed for MEDLINE]


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EBN(edible bird nest) inhibit influenza

Look, another research release by Pubmed,

"Proteases essential for human influenza virus entry into cells and their inhibitors as potential therapeutic agents.Kido H, Okumura Y, Yamada H, Le TQ, Yano M.
Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Kuramoto-cho 3-18-15, Tokushima 770-8503, Japan. kido@ier.tokushima-u.ac.jp

Influenza A virus (IAV) is one of the most common infectious pathogens in humans. Since IVA genome does not have the processing protease for the viral membrane fusion glycoprotein precursors, entry of this virus into cells is determined primarily by host cellular, trypsin-type, processing proteases that proteolytically activate the fusion glycoprotein precursors of IAV. At least five different processing proteases have been identified in the airways of animals and humans. These proteases determine the infectious organ tropism of IAV infection as well as the efficiency of viral multiplication in the airway, and sometimes in the brain. Proteases in the upper respiratory tract are suppressed by secretory leukoprotease inhibitor, and those in the lower respiratory tract are suppressed by pulmonary surfactant which, by adsorption, inhibits the interaction between the proteases and viral membrane proteins. Since protease activities predominate over those of endogenous inhibitory compounds under normal airway conditions, administration of protease inhibitors in the early-stage of infection significantly suppresses viral entry and viral multiplication. Several viral neuraminidase inhibitors are used clinically as anti-influenza virus agents, based on their inhibitory action on viral release from infected cells. Furthermore, protease inhibitors of viral entry could be potentially useful against influenza virus as well as neuraminidase inhibitor-resistant viruses. We also found that ambroxol, a mucolytic and anti-oxidant agent, up-regulates the levels of endogenous protease inhibitory compounds in the airway fluids in early-phase infection, and that clarithromycin, a macrolide antibiotic, increases IgA levels and mucosal immunity through augmentation of interleukin-12 levels in the airway. The combination of neuraminidase inhibitors and protease inhibitors, clarithromycin or ambroxol, could be potentially used as a potent anti-influenza therapy to minimize the emergence of drug-resistant mutant viruses.

PMID: 17311557 [PubMed - indexed for MEDLINE"

Saturday 5 September 2009

燕窝品质如何鉴定?燕窝行业规范化势在必行

中国时报
“燕窝行业规范化势在必行时间:2009-04-08 12:57来源:第一食品网 作者:佚名 点击:26次  
  随着人民生活水平的提高,过去皇家贵族享用的“燕窝”,如今却能城市的大街小巷轻易见到。据不完全统计,最近两年里,仅福州地区,悄然出现的燕窝店就不下七十家,并且这个数目还在进一步扩大,显然燕窝在国内已经发展成一个产业。那么如何来保证消费者的权益及燕窝行业良性健康的发展那?业内人士认为,货源渠道也好,是否商检也好,是否真燕窝也罢,一切问题的根源都在于该行业缺乏一个标准。对此,福州大学生物工程学院表示,将与企业合作,共同制定一个较为统一的标准。

  监管部门:无标准造成执法困绕

  燕窝是金丝燕产蛋时所用的窝巢,因含有较高的营养成分而被人们所青睐。虽然人类食用燕窝的历史很悠久,且在印尼、泰国等地,加工燕窝的企业不在少数。但遗憾的是,至今为止,全球还找不到一个有关燕窝的产品标准。燕窝一直是作为一个具有地域性的“特产”而被当作“农副产品”,而非“加工品”。即使是以燕窝为原料加工制剂、保健品等产品的企业,也只是以一般性食品或饮料的产品为标准。

  福州大学生物工程学院的倪莉博士介绍,由于没有标准,商家为了迎合消费者的喜好,极力从外观上进行刻意掺假、造假。通过改变燕窝的形状、颜色,如染色、漂白、沾胶等尽可能将燕窝做得“漂亮”以吸引消费者,而不是从燕窝的内在品质出发来进行优劣等级的划分。

  这种状况不仅给消费者造成了困挠,同时,也给各地海关、检验检疫部门、质检部门在执法时造成困难。消费者认为,在选购时无从评判,监管部门也埋怨——“检验时无从依据如何检验?怎样出具让人信服的数据?”。因而,大多数城市的海关、检验检疫部门及质检部门都未将燕窝纳入监管范围。

  记者从中心检验所了解到,目前,燕窝的检验都是商家自发送检,检验的项目也是由商家自愿报检,一般只是停留在水分、蛋白质等常规项目的检测上,检测的费用和产品样品都由商家自己承担。“这些数据也只能表明其所含成分,但不能证明这就是真燕窝。”一位负责说。同时,由于没有产品标准,市场抽检也就无从谈起。

  由于划归为无标产品,燕窝的整个行业处于缺乏约束的状态中,燕窝成为名副其实的“三无产品”。需要提醒的是,目前有个别商家以持有出入境检验检疫证为依据来宣扬自己的燕窝产品是市场上唯一的真燕窝,这种宣扬是有失偏颇的,会给消费者造成一定的误导。事实上,即使是经过海关检验检疫的燕窝也只能说明其未被疫情传染,而不能证明其产品的真假优劣。商家各种混乱的概念炒作,也只将整个行业置于更加混乱的境地中。

  科研部门:欲从原料中找出燕窝共性

  福州大学生物工程学院的倪莉博士介绍,目前燕窝行业在全球只有极个别企业执行着自定的企业标准,因此市面上各个商家才会各执一词。只有从燕窝的内在品质中寻找出一个可评判的共性才能真正具有说服力。

  倪博士透露,建立这项燕窝标准的思路是,筛选燕窝中的有效成分,建立燕窝的成分数据库,按燕窝的真实功效来给燕窝划分等级。

  该学院的刘志彬老师是将燕窝做标准研究的具体负责人,他介绍,目前正在进行燕窝标准的研究。但还处于摸索阶段,距离达到国家标准还有一大段路要走。现在进行成份分析,建立燕窝数据库的阶段。

  刘志彬告诉记者,目前除了福大生物工程学院,清华大学和部分医学院也正在进行相关的研究。“目前在进行的国家标准研究,是按保健品的标准,而不是按食品标准来做。因为老百姓吃燕窝,多数认为燕窝营养价值高,吃了对身体好,同时燕窝的售价也很高,不是一般食品的价格。而且目前市面上掺假的燕窝,所加入的明胶、猪皮蛋白等,都符合食品要求,卫生要求,但会影响燕窝的营养成分和食用效果。因此,把燕窝划分到保健品的范畴,制作国家标准才有意义。”
 同时,两位专家也表示,燕窝标准的研究尚有许多难题。比如燕窝作为一个“非制造”产品,其品质及营养成分会因产地的不同,燕子所食食物的不同,品种的不同而呈现出不同的特点,如何横向对比个产地燕窝品质和纵向为某一类燕窝划分等级将是学术难题。

  商家:欲争标准话语权

  由于燕窝行业的标准缺失,给少数以“品质”为追求、并欲在该行业有所为的燕窝商造成了困挠。在燕窝品质上,他们并未因为过多的投入和注重而获得应有的竞争优势。这些燕窝企业深刻意识到:只有掌握了标准的话语权才能真正掌舵行业发展的未来。

  在印尼从事燕窝行业近三十年的印尼华桥YANTO先生是印尼燕窝协会的副会长,据他透露,作为最大的燕窝产地,印尼这么多年来也没有制定出一个燕窝标准。他告诉记者,作为行业协会的负责人之一,他与协会成员们曾共同将十几公斤的燕窝寄往美国、日本、马来西亚等数个不同国家去检测,以其从中找出一个共同性。检验结果却令他们吃惊:每份检验报告的数据并不一致。

  2008年,印尼华桥YANTO先生经过两年的筹备,在福州开办了第一家“古法手法”原料加工燕窝机构——融道燕窝。行业的不正常竞争再一次勾起其进行行业标准制定的愿望。“燕窝行业标准的制定,主要难题在于技术层面。在经过印尼那一次检测风波后,我们想到要从原料出发,寻找出燕窝的共通点。但单靠我们一家企业还是不行的,我们希望联合几家燕窝商共同来完成这个任务。”

  福建天天福燕窝在福建市场上颇有些影响力,在当前市场话语混乱的状况下,该企业受到了不小的影响。该企业的市场部经理朱生友称,为了赢得未来市场。该企业正积极与科研部门配合,希望借助科研手段找出燕窝的共通指标。

  “我们不愿意与其它燕窝商打无谓的口水战。没有标准,任何语言都是苍白的,为了企业未来的发展,我们将不惜血本进行标准的研发。”天天福燕窝的负责人称。”For more information about Pure Edible Birdnest,Please visit Pure Birdnest

Wednesday 2 September 2009

Are You Looking For Analysis Report on Edible Birdnest?

Dear All,

Are you having need to have analysis report on your edible birdnest?

Do you have need to have your own birdnest processing factory?

Please refer to the information extracted from University.

"Strategic Business Unit : Edible Bird’s Nest
Edible bird’s nest SBU is a combination of research and commercialization opportunity development. We have two principal objectives - one is to combine the experience of scientists and engineers from various disciplines to encourage high-quality, collaborative research, second, to guide and assist the client to find the niche market of products commercial value.

Ebn SBU provides consultation, research and products development in the environment of academics and the industry to promote sustainable and cost effective solutions for products, process and performance.

Focus area
Edible bird’s nest products development and characterization

Swiflet farming technology and registration.
Swiflet farming is a booming business. With swiflet farming, farmers could generate a massive amount of passive income. Swiflets especially Collocalia fusiphaga built their nest and their nests are the most highly priced. In Malaysia, bird’s nest businesses are in the growing phase, this business would be a big contribution to our country’s economic growth. With these high benefits of bird’s nest, we at CEPP provide consultation of swiflets farming facilities, farming technology, bird’s nests house set up and registration of swiflets farming.
Bird’s nest cleaning process
Raw bird’s nests need to be cleaned due to high of contaminants. A good bird’s nest cleaning process is required in producing high quality bird’s nest. Therefore in the market, cleaning process which requires chemical reaction will produce low quality bird’s nests and harmed the consumers. We successfully developed the bird’s nest cleaning process without any usage of toxic chemicals, bleaching agents, preservatives, colorants, or additives used in the cleaning process.
Bird’s nests analysis and certification
In Malaysia, this bird’s nest businesses grow positively but the analysis of the bird’s nest is still few. The non-genuine bird’s nests exist in the market. This problem can be solved by bird’s nest analysis and certification. At CEPP, the analyses provided are protein analysis, moisture analysis, amino acid and sialic acid analysis. The analyses can be used to authentic the bird’s nest.

Development and process design for bird’s nests products.
From raw bird’s nest, the manufacturers have produced lots of bird’s nest based products thanks to the new technologies that we have in Malaysia. But this product development need to expend more and the benefits from the bird’s nests should be manipulated massively. Consumers can gain benefits from the bird’s nest, not only from the bird’s nest itself, but in a different form of bird’s nest. We at CEPP have the ability to develop bird’s nest products to suit your needs. We can consult and lead you the way to enhance your business in bird’s nest products and branding.
Research activities

Current research
Biosatellite projects - Bird’s nest physiochemical profiling and purification process development.
Prime Minister Top down grant - Anti-ageing properties determination of the edible bird’s nest.
List of completed research project
Bird’s nest extraction process
New bird’s nest cleaning process
Development of standard procedure and method for genuine edible bird’s nest identification
Development of standard procedure and method for genuine edible bird’s nest identification
Recovery of bird’s nest by downstream processing method
Protein characterization of bird’s nest
Partial separation and purification of solubilized edible bird’s nest protein by ion exchange chromatography
Formulation of bird’s nest extract into cosmeceutical products
Comparative study of edible bird’s nest, white fungus, jelly, fish swimming bladder and egg white
Publications
C. Y. Chan (2004). Recovery of bird’s nest downstream processing method. Universiti Teknologi Malaysia: B. Eng. Thesis.
I. A. W. Tan (2004). Protein Characterization of the Bird’s Nest. Universiti Teknologi Malaysia: B. Eng. Thesis.
S. W. Chan (2005). Partial Separation and Purification of Solubalized Edible Bird’s Nest Protein by Ion Exchange Chromatography. Universiti Teknologi Malaysia: B. Eng. Thesis.
X. Y. Tay (2005). Formulation of Bird’s Nest Extract into Cosmaceutical Products. Universiti Teknologi Malaysia: B. Eng. Thesis.
Y. P. Heng (2005). Comparative Study of Edible Bird’s Nest, White Fungus, Jelly, Fish Swimming Bladder and Egg White through Gel Electrophoresis and HPLC. Universiti Teknologi Malaysia: B. Eng. Thesis.
T. H. Lee, T. T. Tan, I. A. W. Tan, M. R. Roji, R. A. Aziz and C. T. Lee. (2005). Preliminary Characterization of Bird’s Nest. Malaysia Science and Technology Congress (MSTC). 18-20 April 2005. Kuala Lumpur: Confederation of the Scientific and Technological Association in Malaysia (COSTAM), 130.
T. H. Lee, T. T. Tan, C. Y. Chan, C. T. Lee, R. A. Aziz and M. R. Roji. (2005). Preliminary Study of Bird’s Nest Recovery Process. Malaysia Science and Technology Congress (MSTC). 18-20 April 2005. Kuala Lumpur. Confederation of the Scientific and Technological Association in Malaysia (COSTAM), 131.
E. T. T. Tan, T. H. Lee, M. R. Sarmidi, R. A. Aziz and C. T. Lee. (2006). Morphological and Proximate Studies of Edible Bird’s Nest (EBN). Asian pacific Confederation of Chemical Engineering (11th APPCChE Congress). 27-30 August 2006. Kuala Lumpur, Malaysia. The Institution of Engineering, Malaysia.
E. T. T. Tan (2007). Physiochemical and Biochemical Properties of Edible Bird’s Nest. Universiti Teknologi Malaysia. M. Eng. Thesis.
Media publication:
Malaysia Inventions Innovation, 23 Mei 2003, TV 2
New Straits Times, 18 April 2004 – Carte Blanch
Berita Harian, 22 April 2004 – Kaedah Terbaru Uji Tahap Penceluran Hanya 5 Minit.
China Pres, 18 April 2005 – Genuine Bird’s Nest
China Press, 7 June 2005
Awards
Saintis cemerlang 2004 awarded to Mr. Lee Ting Hun by Kementerian Pengajian Tinggi Malaysia.
Bronze medal in S&T Expo 2004 for Bird’s Nest Extraction Process.
Bronze medal in R&D Expo IPTA 2005 for Bird’s Nest Extraction Process.
Silver medal in ITEX 2003 in Development of Blanching Diagnostic Kit or Detection Instrument for Vegetables and Fruits.
Gold Medal in 32nd International Exhibition of Inventions, New Techniques and Products, Geneva, 2004 in Development of Blanching Diagnostic Kit or Detection Instrument for Vegetables and Fruits.
Bronze medal in R&D Expo IPTA 2005 in Development of Blanching Diagnostic Kit or Detection Instrument for Vegetables and Fruits. "